During the 15th century, the palace became the headquarters of the Banco di San Giorgio, a powerful credit institution that managed the public debt of the Republic of Genoa and is considered by many to be the world's first modern bank. In 1570 the palace was expanded and modified, becoming an example of medieval civil architecture alongside Renaissance architecture. Lazzaro Tavarone, in 1610, enriched the facades with frescoes, including one depicting St. George slaying the dragon.

Over the years the building has undergone major restorations. In the 19th century, Alfredo D'Andrade oversaw the restoration of the medieval part, while the 16th-century part was restored by Orlando Grosso.

Today San Giorgio houses the Port Authority of Genoa and remains a symbol of the city's historical and cultural heritage. Visitors, by appointment or during temporary exhibitions, can admire the Sala del Capitano del Popolo, the grand staircase, and the Loggia.

Andrea Pitto Palace (Piazza Fossatello, 3, 16124 Genova GE)

The Andrea Pitto Palace, located in the historic center of Genoa, was originally owned by the Branca Doria family, also mentioned in Dante Alighieri's Inferno, the palace appears in the rolls as early as 1599. Believed to be the oldest of the palaces facing St. Matthew's Square, it was expanded in the 15th century by incorporating several medieval units.

The palace is known for its late 15th-century style inner courtyard, characterized by a staircase that runs along two sides of the arcade, supported by a tall ringed column that establishes an elegant connection between the stairs and the arcade. After suffering damage in World War II, the palace was restored, highlighting its Romanesque portico with octagonal pillars and double-arched arches.